Mutation Rate Analysis in Clinical Saccharomyces cerevisiae Strains

This dataset supports a study investigating the effect of known mutator alleles (MLH1 and PMS1) on mutation rates in clinical Saccharomyces cerevisiae yeast strains. The analysis includes genomic and phylogenetic data, finding that the incompatible allele combination only marginally elevates mutation rate. The dataset is associated with research published in 2020.

Use Cases

• Analyze the relationship between MLH1 and PMS1 allele combinations and observed mutation rates in clinical isolates.
• Perform genomic analyses to search for historical signatures of elevated mutation rates across the studied strains.
• Conduct phylogenetic analyses to understand the evolutionary context of mutator alleles in facultatively sexual populations.
• Investigate the role of background genetic modifiers in dampening the phenotypic effect of mutator alleles.

Strengths

• Data is associated with peer-reviewed research investigating a specific evolutionary genetics hypothesis.
• Focuses on clinical isolates of Saccharomyces cerevisiae, providing a relevant context for microbial pathogenicity studies.
• Explicitly tests the theoretical prediction about mutator allele fixation in sexual populations with observational evidence.

Limitations

• The specific data format, column structure, and row count are not provided in the input.
• The dataset scope is limited to a specific cluster of clinical yeast isolates, which may limit generalizability.
• The analysis is based on a 2020 publication, and newer strains or findings may not be included.

Provenance

Source

Dryad digital repository.

Collection Method

Genomic and phylogenetic analysis of clinical Saccharomyces cerevisiae strains.

Freshness

Last updated 2020-06-24.