Parkinson's Disease Impulse Control Disorder Longitudinal Cohort

A multicentre longitudinal cohort of 411 Parkinson's disease patients with ≤5 years disease duration at baseline, followed annually for up to 5 years. The study investigates the dose-effect relationship between dopamine replacement therapy and impulse control disorders, reporting a 5-year cumulative ICD incidence of 46.1%.

Use Cases

• Analyze the longitudinal association between dopamine agonist (DA) lifetime average daily dose and impulse control disorder (ICD) prevalence using Poisson models.
• Model the 5-year cumulative incidence of ICDs segmented by DA ever-use status (51.5% for ever-users vs. 12.4% for never-users).
• Study the temporal progression of ICD prevalence from the baseline measurement of 19.7% to 32.8% after 5 years of follow-up.
• Examine the relationship between duration of DA treatment and ICD resolution rates after drug discontinuation.

Strengths

• Longitudinal design with an average patient follow-up of 3.3 years (SD=1.7y) across up to 5 annual visits.
• Clinical data from 411 patients, including 40.6% women with a mean age of 62.3 years at study outset.
• High treatment coverage with 356 patients (86.6%) having taken dopamine agonists at least once, enabling robust exposure analysis.
• ICD evaluation performed via face-to-face semi-structured interviews with movement disorder specialists.

Limitations

• Sample size of 411 patients may limit statistical power for subgroup analyses, such as comparisons between specific drug regimens.
• Geographic scope of the multicentre cohort is unspecified, potentially limiting generalizability to other populations.
• Data focuses on patients with ≤5 years disease duration at baseline, excluding those with longer disease histories.

Provenance

Source

Dryad

Collection Method

Data from a multicentre longitudinal cohort of consecutive Parkinson's disease patients, with ICDs evaluated during face-to-face semi-structured interviews with specialists.

Time Range

Patients followed annually for up to 5 years.

Freshness

2020-06-24

Geography

Multicentre cohort; specific regions not stated.