Resting-State fMRI Connectivity Data from Human and Rat Subjects

Featuring resting-state functional connectivity MRI data from 18 healthy human subjects and 18 anesthetized rats. It includes correlation analyses with and without global signal correction and spatial smoothing, focusing on the properties of negative correlations. The data was generated to investigate the physiological basis of negative correlations in brain connectivity.

Use Cases

• Compare the effect of global signal correction on the number of significant positive and negative connections between brain regions.
• Analyze the spatial distribution of negative connections, which were observed primarily between cortical and non-cortical structures.
• Investigate the time-lag dependency of correlation significance, contrasting positive connections (less significant with lag) and negative connections (more significant with lag).
• Examine the absence of negative connections between bilateral homologous regions in both human and rat data.

Strengths

• Includes data from two species (18 humans and 18 rats), enabling cross-species comparison.
• Provides analyses under four distinct conditions: with/without global signal correction and with/without spatial smoothing.
• Focuses on a specific, less-studied phenomenon: negative correlations in resting-state fMRI connectivity.

Limitations

• Sample size is limited to 18 subjects per species, which may constrain statistical power for some analyses.
• The dataset is derived from a specific methodological study, so its generalizability to other acquisition protocols is unknown.
• Data availability details like file formats, size, and specific column structures are not provided in the input.

Provenance

Source

Dryad digital repository.

Collection Method

Resting-state functional connectivity MRI scans were processed; correlations between anatomy-based brain regions were calculated and analyzed.

Freshness

Last updated in June 2020.