Ventricular Dead Space Volume Estimates from Porcine Cardiac Experiments

Data from a 2020 study validating a method to estimate ventricular dead space volume (Vd) in six sedated male Pietrain pigs. The dataset supports the method's validation through linear extrapolation of Frank-Starling curves, showing strong correlation coefficients (R=0.78 and R=0.80) and physiologically reasonable Vd values ranging from 44.3% to 82.6% of baseline end-systolic volume.

Use Cases

• Validate the linear extrapolation method for Vd estimation using the reported correlation coefficients (R=0.78 and R=0.80) across different cardiac states.
• Analyze the relationship between Vd values and cardiac states (healthy baseline to septic shock) induced by endotoxin infusion.
• Compare the two linearly extrapolated y-intercept (Vd) values for each subject, where variation was reported as no more than 7.8%.

Strengths

• Validation cohort includes six subjects, enabling method demonstration across varied conditions.
• Strong linear correlation coefficients (R=0.78 and R=0.80) support the extrapolation method's reliability.
• Physiologically reasonable Vd values, reported as percentages (44.3-53.1% and 49.3-82.6%) of baseline end-systolic volume, indicate method validity.

Limitations

• Small sample size of six subjects limits statistical power and generalizability of findings.
• Data is derived exclusively from male Pietrain pigs, which may not be representative of other populations or species.
• Specific data structure, column names, and row counts are not provided, complicating direct analytical use.

Provenance

Source

Dryad, authored by Shaun Davidson.

Collection Method

Data collected from experiments on six sedated and anaesthetised male Pietrain pigs, with Vd estimated via linear extrapolation of Frank-Starling curves during recruitment manoeuvres.

Time Range

Study published in 2020.

Freshness

Last updated 2020-06-24.