Leech Heart Interneuron Bursting Activity and Na+/K+ Pump Dynamics

Electrophysiological recordings and mathematical model outputs investigating the interaction between the Na+/K+ pump and h-current in leech heart interneurons. Created by Daniel Kueh and updated in 2020, the data documents changes in neuronal bursting periods under pharmacological manipulations including monensin and strophanthidin. The collection includes both biological experimental results and synthetic data from a Na+ dynamics model.

Use Cases

• Analyzing the effect of monensin on the bursting period of heart interneurons
• Validating mathematical models of Na+ dynamics against biological electrophysiology data
• Comparing neuronal activity changes when h-current is blocked by Cs+ versus control conditions

Strengths

• Integrates biological experimental data with mathematical model simulations
• Includes multiple pharmacological conditions such as monensin stimulation and Cs+ h-current blocking
• Focuses on specific central pattern generator (CPG) neuron dynamics

Limitations

• Specific to leech (Hirudo medicinalis) neurobiology, limiting direct application to vertebrate systems
• Unknown file structure and record count due to lack of detailed metadata
• Temporal staleness as a one-time publication-linked dataset

Provenance

Source

Daniel Kueh via Dryad

Collection Method

Electrophysiological recording and mathematical simulation

Freshness

Static research dataset last updated in June 2020.