Paraneoplastic Neuronal Intermediate Filament Autoimmunity Patient Data

Clinical and laboratory data from 65 patients with paraneoplastic neuronal intermediate filament (NIF) autoimmunity. It includes patient demographics, specific NIF-IgG antibody profiles, associated neurological syndromes, and cancer diagnoses. The data was used to characterize two distinct patient groups based on the presence or absence of neurofilament light chain (NF-L) IgG.

Use Cases

• Analyze the correlation between NF-L-IgG presence and specific neurological syndromes like cerebellar ataxia or encephalopathy.
• Investigate the association between NIF-IgG profiles (e.g., number of specific antibodies detected) and cancer types, particularly neuroendocrine lineage carcinomas.
• Compare clinical outcomes, such as response to immunotherapy, between NF-L-IgG positive and negative patient groups.
• Examine demographic factors like patient age and gender distribution across different NIF autoimmunity profiles.

Strengths

• Data is derived from a study of 65 patients, providing a defined cohort for analysis.
• Findings are supported by multiple laboratory confirmation methods, including immunofluorescence and cell-based assays.
• Clinical correlations are presented with statistical significance values (e.g., p=0.006, p<0.0001).

Limitations

• The sample size of 65 patients is relatively small for robust subgroup analyses.
• The dataset is archival, representing a retrospective analysis which may introduce selection bias.
• Immunotherapy outcome data is available for only 7 patients, limiting conclusions on treatment efficacy.

Provenance

Source

Dryad digital repository.

Collection Method

Retrospective analysis of archived patient and control serum and CSF specimens using immunofluorescence, western blot, mass spectrometry, and cell-based assays.

Time Range

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Freshness

Data was last updated in June 2020.

Geography

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