Primary Biliary Cholangitis Patient MRI and Cognitive Test Data

20 female patients with primary biliary cholangitis (PBC) and 20 female age-matched controls were examined for fatigue, psychological symptoms, and cognitive performance. The dataset includes results from clinical questionnaires, established cognition tests, a computerized attention battery, and 3 Tesla MRI scans analyzed with voxel-based morphometry and diffusion tensor imaging. It was created by Roman Zenouzi and last updated in June 2020.

Use Cases

• Correlate voxel-based morphometry (VBM) results with cognitive test scores to investigate structural brain changes in PBC patients.
• Analyze diffusion tensor imaging (DTI) data against fatigue questionnaire levels to assess potential white matter abnormalities.
• Compare verbal fluency test performance between the PBC patient cohort and healthy controls to identify specific cognitive deficits.
• Evaluate reaction time data from the computerized attention battery for correlations with psychological symptom scores.

Strengths

• Case-control study design with a matched cohort of 20 PBC patients and 20 healthy controls.
• Multi-modal assessment combining clinical questionnaires, cognitive tests, and advanced 3 Tesla MRI scans (T1-weighted and DTI).
• Analysis includes specific, established methods like voxel-based morphometry and diffusion tensor imaging for structural brain investigation.

Limitations

• Small sample size of 20 patients limits statistical power and generalizability of findings.
• Study population is exclusively female, which may not represent the broader PBC patient demographic.
• Data is cross-sectional from a single time point, preventing analysis of disease progression or treatment effects over time.

Provenance

Source

Dryad

Collection Method

Data collected from a case-control study involving clinical assessments, cognitive testing, and 3 Tesla cerebral MRI scans.

Freshness

Data was last updated in June 2020.