Peri-Ictal Apnea and Asystole in Generalized Convulsive Seizures

Comprising data from a prospective, multi-center study analyzing autonomic and breathing biomarkers for Sudden Unexpected Death in Epilepsy (SUDEP). It includes observations from 148 generalized convulsive seizures across 87 adult patients with intractable epilepsy. The study characterized phenomena such as ictal central apnea, post-convulsive central apnea, and asystole.

Use Cases

• Analyze the incidence of post-convulsive central apnea (PCCA) across focal and generalized epilepsy types to assess its role as a SUDEP biomarker.
• Investigate the correlation between ictal central apnea (ICA) and focal epilepsy in the cohort of 23 patients where it was observed.
• Examine the relationship between rhythmical post-ictal muscle artifact and stertorous breathing using the provided odds ratio (OR 3.856).
• Calculate SUDEP and near-SUDEP incidence rates (e.g., 10.2/1000 patient-years) based on cases of PCCA occurring concurrently with asystole.

Strengths

• Data originates from a prospective, multi-center study design involving 87 patients.
• Includes analysis of 148 generalized convulsive seizures.
• Reports specific incidence rates for near-SUDEP (10.2/1000 patient-years) and probable SUDEP (5.1 per 1000 patient-years).

Limitations

• Sample size is limited to 87 patients and 148 seizures, which may constrain statistical power.
• Patient cohort is restricted to adults (≥18 years old) with intractable epilepsy, limiting generalizability.
• Specific columnar data structure, file formats, and raw data size are unknown.

Provenance

Source

Dryad digital repository.

Collection Method

Prospective, multi-center epilepsy monitoring study analyzing video EEG, thoraco-abdominal excursions, nasal airflow, capillary oxygen saturation, and electrocardiography.

Freshness

Data was last updated in June 2020.