Serum Neurofilament Prognostic Data for Clinically Isolated Syndromes

A retrospective analysis of 222 patients with a first demyelinating event, assessing the prognostic value of serum neurofilament light chains (Nfls) for conversion to multiple sclerosis. The study includes baseline serum Nfls, CSF, MRI, and clinical data, with a mean patient follow-up of 100.6 months. It finds serum Nfls levels are prognostic for both Clinically Defined Multiple Sclerosis and McDonald 2017 MS.

Use Cases

• Analyze the association between baseline serum Nfls levels and the development of Clinically Defined Multiple Sclerosis (CDMS) using patient clinical data.
• Investigate the relationship between serum Nfls and baseline MRI features, such as the number of T2 and Gd-enhancing lesions, for prognostic modeling.
• Model the risk of conversion to McDonald 2017 MS based on serum Nfls levels, adjusting for established prognostic factors like oligoclonal bands' presence.
• Examine the correlation between serum Nfls levels and baseline disability scores within the patient cohort.

Strengths

• Contains data from 222 patients with a clinically isolated syndrome, providing a substantial clinical cohort.
• Features a long mean follow-up period of 100.6 months for tracking disease progression.
• Includes multiple data modalities: serum biomarkers (Nfls), CSF analysis, MRI results, and clinical assessments.

Limitations

• Retrospective study design may introduce selection bias compared to a prospective cohort.
• Sample is from a single neurological department, which may limit geographic and demographic generalizability.
• Specific column names and data structure are not provided, complicating direct analysis.

Provenance

Source

Gloria Dalla Costa via Dryad.

Collection Method

Retrospective analysis of patient records from a neurological department.

Time Range

Patient admissions between 2000 and 2015.

Freshness

Data covers patient admissions from 2000 to 2015, with the dataset last updated in 2020.

Geography

Patients admitted to a single neurological department; specific location not stated.