Motor Speech Impairment in Primary Progressive Aphasia Patients

Sixty-four patients with primary progressive aphasia were evaluated at baseline, with a subset of 39 assessed longitudinally. The dataset contains quantitative articulation rate measurements from spontaneous speech and baseline MRI-derived cortical thickness data to investigate motor speech impairment and its neuroanatomical basis.

Use Cases

• Analyze baseline articulation rate differences across PPA subtypes and severity levels to identify motor speech impairment markers.
• Apply linear mixed-effects models to articulation rate data from 39 patients to track its decline over a one-year period.
• Correlate baseline articulation rate measurements with cortical thickness from MRI scans to localize atrophy in left-hemisphere motor speech regions.

Strengths

• Contains data from 64 patients with primary progressive aphasia, a specific neurodegenerative population.
• Includes longitudinal data for a subset of 39 patients, enabling analysis of decline over a one-year period.
• Combines quantitative speech measures (articulation rate) with neuroimaging data (MRI cortical thickness) for multimodal analysis.

Limitations

• Sample size is limited to 64 patients, which may restrict statistical power for subgroup analyses.
• Longitudinal follow-up data is available for only 39 patients, reducing the cohort for time-series analysis.
• The dataset is specific to primary progressive aphasia, limiting generalizability to other speech or motor disorders.

Provenance

Source

Dryad digital repository.

Collection Method

Clinical evaluation and MRI scans from a study of patients with primary progressive aphasia.

Time Range

Baseline and one-year longitudinal follow-up.

Freshness

Data was last updated in June 2020.