Revised ALS Clinical Trials Consensus Guidelines and Recommendations

Leonard H van den Berg and a committee of 140 international ALS experts published revised consensus guidelines in 2020. The dataset contains 112 recommendations across nine research areas, with 15 prioritized as having the greatest potential for impact. It was developed using a modified Delphi process following a face-to-face workshop.

Use Cases

• Analyze the 112 recommendations across nine areas like Pre-clinical studies and Biomarkers to identify research priorities.
• Study the 15 prioritized recommendations to understand expert consensus on critical improvements for ALS trial design.
• Examine the guidelines on Outcome measures and Statistical considerations to inform the development of new clinical trial protocols.
• Use the recommendations on Biological and phenotypic heterogeneity to guide patient stratification strategies in ALS research.

Strengths

• Contains 112 specific, expert-vetted recommendations for ALS clinical research.
• Developed by a large, diverse consensus committee of 140 international ALS community members.
• Includes 15 prioritized recommendations identified as having the greatest potential impact.
• Guidelines were refined through a structured modified Delphi process and public review.

Limitations

• The dataset consists of textual guidelines and recommendations, not quantitative or tabular data for direct computational analysis.
• As consensus guidelines, the content reflects expert opinion and may not be backed by newly published empirical data.
• The scope is specifically focused on ALS clinical trials, limiting generalizability to other neurological disorders.

Provenance

Source

Leonard H van den Berg and an international ALS consensus committee.

Collection Method

Developed via a modified Delphi process involving a two-day workshop and public review.

Time Range

Guidelines published in 2020.

Freshness

Published in 2020.

Geography

International, based on input from a global committee.