Mouse Embryo Glucose Metabolism Data During Chorioallantoic Branching

Mouse embryo data from a study investigating metabolic rewiring during chorioallantoic branching. The research used metabolome analysis with mass-labeled glucose and imaging mass spectrometry to visualize lactate-rich tissues. The dataset supports findings on the suppression of glycolytic enzymes PFK-1 and aldolase and the role of the Lin28a gene.

Use Cases

• Analyze the redirection of glucose carbon flow into the pentose phosphate pathway via suppression of PFK-1 and aldolase.
• Model the relationship between Lin28a gene expression and observed changes in glucose metabolism during chorioallantoic branching.
• Use imaging mass spectrometry data to correlate lactate pool size with specific tissues like the neural tube, somites, and head mesenchyme.
• Investigate the fractional contribution of glycolysis to lactate biosynthesis across different embryonic developmental stages.

Strengths

• Includes data from imaging mass spectrometry visualizing metabolite distribution in specific tissues.
• Study links metabolic changes to a specific developmental stage (chorioallantoic branching) and a genetic regulator (Lin28a).
• Dataset is published under a CC0 1.0 public domain dedication license.

Limitations

• Sample size and data volume are unspecified, limiting assessment of statistical power.
• Data is specific to mouse embryos, which may limit direct applicability to other species.
• The dataset's structure, available columns, and file formats are unknown, complicating direct usability.

Provenance

Source

Dryad digital repository.

Collection Method

Metabolome analysis with mass-labeled glucose and imaging mass spectrometry.

Time Range

null

Freshness

Last updated in June 2020.

Geography

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