Central Artery Hemodynamics in Wild-Type and Fibulin-5 Deficient Mice

Featuring computational model results comparing central artery biomechanics in adult wild-type and fibulin-5 deficient mice, a model of early vascular ageing. Findings are examined as a function of sex, with models informed by micro-computed tomography imaging and in vivo ultrasound and pressure measurements.

Use Cases

• Analyze sex-dependent differences in pulse wave velocity and regional arterial stiffening between mouse genotypes.
• Compare local pulse pressures at the renal arteries, a quantity difficult to measure experimentally, across mouse models.
• Examine characteristics of the peripheral vascular bed that may differ with disease using fluid-solid interaction model outputs.
• Study the relationship between biaxial wall stiffness, thickness, and perivascular support in mouse-specific computational models.

Strengths

• Data is derived from mouse-specific computational models informed by multiple experimental modalities including micro-CT and in vivo ultrasound.
• Models capture three-dimensional unsteady flows and pulse wave characteristics for the central vasculature.
• Includes comparisons across two mouse genotypes (wild-type and fibulin-5 deficient) and as a function of sex.
• Published under a permissive CC0 1.0 license for broad reuse.

Limitations

• The dataset consists of computational model outputs, not raw experimental measurements, which may limit validation against primary data.
• Sample size (number of individual mouse models) is not specified in the provided information.
• Data is specific to a mouse model of vascular ageing, which may limit direct translation to human physiology.

Provenance

Source

Dryad digital repository.

Collection Method

Generated from a workflow combining in vivo and in vitro biomechanical data to build mouse-specific computational fluid-solid interaction models.

Freshness

Last updated in June 2020.