Mouse Brain and Olfactory Signals Shaping Nasal Cartilage

A collection of experimental data from mutant mice investigating how brain-derived Sonic Hedgehog (SHH) and olfactory epithelium signals control the morphogenesis of the cartilaginous nasal capsule. The research reveals these neural signals shape the nasal capsule, which subsequently influences the development of surrounding membranous facial bones. The data was authored by Marketa Kaucka and was last updated in June 2020.

Use Cases

• Analyze the role of brain-derived Sonic Hedgehog (SHH) signals in the induction of the nasal septum and posterior nasal capsule.
• Investigate the control of nasal capsule roof formation by signals originating from the olfactory epithelium.
• Study the impact of nasal capsule cartilage geometry on the shaping of adjacent membranous facial bones during development.
• Examine genomic regulatory regions controlling SHH production in mutant mice to understand facial cartilage morphogenesis mechanisms.

Strengths

• Data is derived from controlled experiments with mutant mice, a standard model for developmental biology.
• The study investigates a specific, novel mechanism linking neural signals to facial cartilage and bone development.
• Dataset is published under a permissive CC0 1.0 public domain license.

Limitations

• The specific data format, size, row count, and column structure are unknown, limiting immediate analytical utility.
• The dataset is focused exclusively on the Mus musculus (mouse) model, limiting direct applicability to other species without further study.
• Data recency is limited, with the last update recorded in mid-2020.

Provenance

Source

Dryad digital repository.

Collection Method

Experimental data from developmental biology studies on mutant mice.

Freshness

Last updated on 2020-06-30.