Rat Phosphoproteomics Data for Synthetic Torpor Cardioprotection Study

University of Bristol researchers generated phosphoproteomic data from 12 rats to study synthetic torpor. The dataset contains output from tandem mass tag phosphoproteomic mass spectroscopy analysis, comparing 5 rats in synthetic torpor with 7 controls. It was created to investigate mechanisms of organ protection from ischaemia-reperfusion injury.

Use Cases

• Identify cardiac phosphoproteomic signatures of synthetic torpor based on the mass spectroscopy analysis.
• Compare cell survival and stress tolerance pathway activation between torpor and control groups based on the phosphoproteomic analysis.
• Investigate the cardioprotective mechanisms independent of hypothermia based on the described ex vivo heart model.
• Validate potential biomarkers for ischaemia-reperfusion injury protection based on the reported ~40% reduction in infarct size.

Strengths

• Data is derived from a controlled experimental design with 12 rats (5 treatment, 7 control).
• Findings are linked to a concrete, measured outcome: an ~40% reduction in infarct size.
• Analysis includes phosphoproteomic profiling, which suggests protein-level mechanistic insights.

Limitations

• Row count and specific data dimensions are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset scale is limited to a single species (rat) and a specific experimental model.

Provenance

Source

University of Bristol, author Meg Elley.

Collection Method

Tandem mass tag phosphoproteomic mass spectroscopy analysis of cardiac tissue from rats.