Neurotransmitter Responses to 258 Neuropsychiatric Drugs in Rats

2020 data from experiments comprising 110,674 rats presents neurotransmitter response patterns for 258 clinically approved and experimental neuropsychiatric drugs. The dataset, authored by Hamid R. Noori, was used to analyze links between molecular drug action and neurobehavioral effects, revealing mismatches between drug classifications and systems-level neurotransmitter patterns.

Use Cases

• Analyze neurotransmitter response patterns across 258 neuropsychiatric drugs to identify novel therapeutic classes.
• Investigate the relationship between predicted drug-target interactions and brain region-specific neurotransmitter responses.
• Compare experimental and clinically approved drug effects using neurotransmitter response data from rat models.

Strengths

• Data is derived from a large-scale study involving 110,674 rat subjects.
• Covers a wide scope of 258 different neuropsychiatric drugs, including experimental compounds.
• Released under a permissive CC0 1.0 public domain license for unrestricted use.

Limitations

• Data is limited to rat models, which may not fully translate to human neurobiology.
• The dataset's last update was in 2020, potentially missing recent drug discoveries.
• Specific columnar structure, file formats, and sample size per drug are not detailed in the provided input.

Provenance

Source

dryad

Collection Method

Experimental data from neurotransmitter response patterns measured in rats.

Freshness

Last updated 2020-06-24.