HNF4A Promoter Occupancy Data for Post-Natal Hepatocyte Differentiation

2020 data from a study on liver-specific TAF4 inactivation in mice investigates promoter occupancy of nuclear receptor HNF4A. The dataset supports analysis of pre-initiation complex formation and RNA polymerase II pausing during post-natal hepatocyte maturation. It was authored by Daniil Alpern and published under a CC0 license.

Use Cases

• Analyze HNF4A occupancy at promoter-proximal cis-regulatory elements to identify binding patterns for post-natal expressed genes.
• Investigate the relationship between TAF4-dependent PIC formation and RNA polymerase II pausing at embryonic expressed genes.
• Model the interaction between the TAF4-TAF12 heterodimer and HNF4A to understand transcriptional regulation in hepatocyte differentiation.

Strengths

• Data originates from a peer-reviewed biological study investigating a specific molecular mechanism.
• Includes findings on both post-natal expressed liver function genes and down-regulated embryonic expressed genes.
• Published under a permissive CC0 1.0 license, allowing unrestricted reuse.

Limitations

• The underlying data files, formats, row counts, and specific column structures are not described.
• Scope is narrowly focused on mouse hepatocyte differentiation, limiting generalizability to other tissues or species.
• Data is from 2020 and may not reflect the most recent research findings in the field.

Provenance

Source

Dryad digital repository.

Collection Method

Generated from a study using liver-specific inactivation in mice (Mus musculus) and subsequent genomic analyses.

Time Range

Study focuses on post-natal developmental stages.

Freshness

Last updated in June 2020.