Household Tuberculosis Transmission Cohort in Peru 2010-2013

Data from a prospective cohort study in South Lima and Callao, Peru, tracks tuberculosis transmission within households from 2010 to 2013. The study includes 1,055 household contacts of 213 multidrug-resistant tuberculosis (MDRTB) index cases and 2,362 contacts of 487 drug-susceptible index cases. It measures the incidence of tuberculosis disease among contacts, with follow-up times of 1,425 and 2,620 person-years for the respective groups.

Use Cases

• Estimate the relative fitness of MDRTB by comparing tuberculosis disease incidence among household contacts of MDRTB versus drug-susceptible index cases.
• Analyze the hazard ratio for tuberculosis disease among contacts, adjusting for confounding variables like contact HIV status and index case sputum smear grade.
• Model transmission dynamics within households using data on contact age, socio-economic status, and follow-up person-years.

Strengths

• Prospective cohort design with 3 years of follow-up data from 2010 to 2013.
• Includes data on 3,417 total household contacts (1,055 MDRTB contacts and 2,362 drug-susceptible contacts).
• Multivariate Cox regression analysis adjusts for key confounders like HIV status and socio-economic status.

Limitations

• Lacks genotyping data for household contacts, limiting the inference of direct transmission.
• Captures incident disease only among household contacts, which may not extrapolate to community transmission.
• Sample is geographically limited to South Lima and Callao, Peru.

Provenance

Source

Louis Grandjean via Dryad.

Collection Method

Prospective cohort household follow-up study.

Time Range

2010 to 2013.

Freshness

Last updated in June 2020.

Geography

South Lima and Callao, Peru.