Rat Brain MRI Anisotropy Data for Concussion Subcortical Lesion Analysis

Diffusion tensor MRI-derived anisotropy index values from over 20,000 voxels registered into a 3D segmented rat atlas covering 150 brain areas. It was generated from a study using a fluid percussion model to concuss the right caudal or rostral cortices in Sprague Dawley rats, with data acquired five days post-injury. The research was conducted by Praveen Kulkarni and published in 2020.

Use Cases

• Analyze anisotropy index values across 150 segmented brain areas to identify subcortical regions with altered microarchitecture post-concussion.
• Compare left and right hemisphere anisotropy values from over 20,000 voxels to detect lateralized effects of rostral versus caudal cortical injury.
• Map the vulnerability of specific nuclei like the central amygdala, laterodorsal thalamus, and hippocampal complex using registered 3D atlas coordinates.
• Correlate MRI-based anisotropy findings from this dataset with subsequent immunohistochemical markers of neuroinflammation from the source study.

Strengths

• Data is derived from over 20,000 voxels, providing high spatial granularity for microarchitectural analysis.
• Values are registered into a 3D segmented and annotated rat atlas covering 150 distinct brain areas for precise anatomical localization.
• The study design includes controlled comparisons between injury sites (rostral vs. caudal cortex) and hemispheres.

Limitations

• The dataset is derived from a specific animal model (rat fluid percussion injury), limiting direct translation to human traumatic brain injury.
• Sample size (number of animal subjects) is not specified, which is critical for assessing statistical power.
• Data is static from a single post-injury time point (5 days), lacking longitudinal tracking of recovery or progression.

Provenance

Source

Dryad digital repository, authored by Praveen Kulkarni.

Collection Method

Generated from diffusion tensor MRI scans of Sprague Dawley rats subjected to controlled fluid percussion concussions on the right cortex.

Time Range

Data corresponds to a post-injury observation point of five days.

Freshness

Data was last updated in June 2020.

Geography

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