Swine Muscle Perfusion Data from DCE-MRI Validation Study

Encompassing results from a validation study of perfusion quantification using dynamic contrast-enhanced MRI with a blood pool contrast agent in seven female pigs. The study induced three stable perfusion levels and analyzed 160 regions of interest (ROIs) in the hind leg musculature. Perfusion parameters were calculated using one- and two-compartment models, with results showing a high correlation (R=0.89) between MRI-derived total flow and ultrasound probe measurements.

Use Cases

• Compare perfusion values from one- and two-compartment models across 160 ROIs to validate model selection via the F-test.
• Analyze the correlation between MRI-derived total flow and ultrasonic Doppler probe measurements (R=0.89, P=10−7) for validation of the DCE-MRI technique.
• Investigate the separation of blood signal into capillary and arteriolar contributions, as performed in 107 of 160 ROIs using the two-compartment model.
• Calculate perfusion parameters like delay, dispersion, blood volume, and mean transit time across different anatomical regions (medial, cranial, lateral, and pelvic thigh muscles, lower leg, bones, skin, fat).

Strengths

• Data is derived from a controlled validation study with three different induced stable perfusion levels in seven animal subjects.
• Analysis includes 160 regions of interest (ROIs) with physiological parameter calculations.
• Results show a strong statistical correlation (R=0.89, P=10−7) between MRI and ultrasound flow measurements.
• Methodology employs a two-compartment tracer kinetic model for absolute quantification in low-perfused tissue.

Limitations

• Small sample size of seven female pigs limits statistical power and generalizability.
• Data is specific to skeletal swine muscle, which may not directly translate to human physiology or other tissue types.
• The study's temporal resolution of approximately 1.5 seconds may not capture very rapid hemodynamic changes.

Provenance

Source

Dryad digital repository, authored by Stefan Hindel.

Collection Method

Experimental data collected via DCE-MRI and ultrasonic Doppler probe during controlled adenosine administration in swine.

Time Range

The time range of the experimental study is not specified in the input.

Freshness

Data was last updated on 2020-06-24.

Geography

The geographic location of the study is not specified in the input.