White Matter Hyperintensities and Stroke Outcomes Meta-Analysis
by Marios K. Georgakis·Updated 6y ago
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Description
A systematic review and meta-analysis of 104 studies involving 71,298 ischemic stroke patients investigates the relationship between baseline white matter hyperintensities (WMH) and long-term clinical outcomes. The analysis, conducted by Marios K. Georgakis and published in 2020, pools relative risks for outcomes including dementia, functional impairment, recurrent stroke, and mortality, finding significant dose-response associations with WMH severity.
Use Cases
Pool relative risks (RR) for dementia, functional impairment, and mortality to quantify the prognostic impact of baseline WMH severity in ischemic stroke patients.
Analyze dose-response patterns between WMH severity categories and the risk of recurrent ischemic stroke or cardiovascular mortality.
Compare the consistency of associations for outcomes like cognitive impairment between MRI- and CT-defined WMH assessments across the included studies.
Perform sensitivity analyses on the pooled RR data, adjusting for covariates like age and stroke severity, to test result stability.
Strengths
Large patient population of 71,298 individuals aggregated from 104 independent cohort studies.
Results are based on systematic review following MOOSE and PRISMA guidelines with a registered protocol (CRD42018092857).
Analysis provides specific pooled relative risk estimates with 95% confidence intervals for multiple long-term outcomes.
Findings remained stable in sensitivity analyses adjusting for age, stroke severity, and cardiovascular risk factors.
Limitations
The dataset comprises aggregated study-level meta-analysis results, not individual patient-level data, limiting granular analysis.
Temporal coverage of the underlying studies is not specified, potentially including older data with outdated diagnostic criteria.
Geographic and demographic representation of the 104 source studies is unknown, which may introduce bias.
Provenance
Source
Dryad digital repository.
Collection Method
Systematic review and meta-analysis of cohort studies sourced from Medline and Scopus.
Freshness
Last updated in June 2020.
Data consists of aggregated meta-analysis results (e.g., relative risks, confidence intervals) rather than raw patient records; users should review the CC0 1.0 license for terms of use.