Neuron and Astrocyte Viability and Signaling Data Under Oxidative Injury

Experimental data from a neuroscience study by Laura Genı́s, measuring cell viability and molecular signaling in neurons and astrocytes under oxidative stress. The description details measurements of cell survival percentages, protein levels (pAKT, pERK, SOD, TXNIP), and gene expression (SCF mRNA) across multiple experimental conditions. The dataset is associated with figures from a research article and is available via the paperswithcode platform.

Use Cases

• Modeling the protective effects of IGF-I on neuron viability based on survival percentage measurements.
• Analyzing pAKT and pERK signaling dynamics in astrocytes under oxidative stress conditions.
• Investigating the role of reactive oxygen species (ROS) and superoxide dismutase (SOD) levels in astrocyte-mediated neuroprotection.
• Studying the relationship between TXNIP expression and cell survival in astrocytes after H2O2 treatment.

Strengths

• The description provides detailed, specific experimental conditions and measured outcomes for multiple figures.
• Data is associated with a formal research article, suggesting a structured experimental design.
• Includes measurements for multiple cell types (neurons, astrocytes) and key signaling molecules (IGF-I, pAKT, pERK, SOD, TXNIP, SCF).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Laura Genı́s via paperswithcode platform.

Collection Method

Likely originates from laboratory experiments measuring cell viability and molecular assays as described.