Mouse and Human Data on Gut-Joint Immune Crosstalk in Arthritis

Nadine Otterbein's research dataset, last updated in April 2026, integrates mouse and human imaging mass cytometry and tissue sequencing data to investigate rheumatoid arthritis pathogenesis. The 12.3 GB repository likely contains experimental results linking gut endothelial barrier impairment, microbial translocation, and systemic immune activation to joint inflammation.

Use Cases

• Modeling gut endothelial barrier changes prior to arthritis onset based on imaging mass cytometry data
• Analyzing microbiota-specific serum IgG responses to translocating bacteria mentioned in the description
• Investigating the therapeutic effects of gut-selective integrin blockade and endothelial barrier enhancement
• Spatial mapping of epithelial–immune interactions in ileal tissues from murine and human samples

Strengths

• Dataset size is 12.3 GB, indicating a substantial volume of experimental data.
• Data integrates findings from both mouse models (CIA) and human tissues.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The description is detailed but does not specify the exact variables or file contents within the repository.

Provenance

Source

Nadine Otterbein via figshare.

Collection Method

Generated from imaging mass cytometry and tissue sequencing in mouse and human studies of rheumatoid arthritis.

Time Range

The experimental timeframe is not specified.

Freshness

Last updated 2026-04-13 12:11:27.

Geography

Geographic coverage of the human samples is not specified.