Data Sheet 1_A 7-gene expression signature predicts immune microenvironment remodeling and

40 lung squamous cell carcinoma patients receiving neoadjuvant chemo-immunotherapy were categorized by pathological response. Bulk RNA sequencing was performed on pre- and post-treatment samples to assess immune cell composition and identify a 7-gene signature. The dataset was authored by Shaoling Li and last updated on March 18, 2026.

Use Cases

• Predicting neoadjuvant chemo-immunotherapy response based on a 7-gene expression signature.
• Analyzing immune microenvironment remodeling from 'cold' to 'hot' phenotypes using bulk RNA-seq data.
• Investigating the association of HOXC13 expression with immune-cell infiltration and patient survival outcomes.
• Validating gene signatures linked to major pathological response in an independent cohort like the OAK database.

Strengths

• Includes paired pre- and post-treatment RNA-seq samples from 40 patients, enabling longitudinal analysis.
• Defines a specific 7-gene expression signature potentially linked to treatment response.
• Patient outcomes are categorized with 75% achieving major pathological response and 25% classified as non-MPR.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is small at 45.3 KB, indicating limited scope.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Shaoling Li.

Collection Method

Bulk RNA sequencing of tumor samples from 40 LUSC patients receiving neoadjuvant chemo-immunotherapy.

Freshness

Last updated 2026-03-18 07:37:31; freshness should be verified.