Compartmental Model for Simulating Gut-Brain Axis Regulation of Gastric Function

A mathematical model of the gut-brain axis, presented in a 1.5 MB PDF file. The model simulates vagal and enteric nervous system pathways to regulate gastric function, including peristaltic activity and pyloric sphincter dynamics. It was authored by Shannon Q. Fernandes and last updated on June 3, 2026.

Use Cases

• Simulating parasympathetic and sympathetic responses on gastric emptying based on the described three-compartment stomach model.
• Investigating the effects of high-calorie liquids on gastric emptying rates based on the described pyloric sphincter regulation.
• Developing model-based control for vagal stimulation therapies based on the described computationally efficient framework.
• Studying the activity of interstitial cells of Cajal under varying gastric volumes based on the described simulation results.

Strengths

• Model incorporates passive stress and dynamic changes in stomach geometry, extending previous work.
• Simulation results are described as aligning with physiological observations, such as inhibitory and excitatory digestive activity.
• The model is described as computationally efficient, suggesting potential for use in closed-loop control applications.

Limitations

• The dataset is a PDF document (1.5 MB); the underlying simulation data, column definitions, and row counts are unavailable.
• Description metadata is limited; actual data quality and model implementation details require manual inspection of the PDF.
• Last updated 2026-06-03 06:18:31; freshness should be verified.

Provenance

Source

figshare

Collection Method

A novel mathematical model introduced by the author, employing a compartmental modeling framework and Michaelis-Menten equations.

Freshness

Last updated 2026-06-03 06:18:31