Data Sheet 1_A feedback loop sustaining neutrophil extracellular trap formation involves S

Mass spectrometry analyses identified seven S100 protein species and ten histone variants released by neutrophils undergoing NET formation. The 1.3 MB PDF, authored by Vanessa de Carvalho Oliveira and last updated in June 2026, describes a feedback loop involving RAGE and TLR2 receptors and its inhibition by albumin. Data supporting the findings are likely contained within the document.

Use Cases

• Identify potential protein biomarkers for NET-related pathologies based on the described S100 proteins and histones.
• Model the protein-protein interaction network in NET formation based on the described binding of S100 proteins and histones to RAGE.
• Investigate the role of albumin as a regulatory factor in inflammatory processes based on its described sequestration of S100 proteins.

Strengths

• Data is derived from mass spectrometry analyses, a high-resolution analytical technique.
• The study design includes specific receptor antagonism experiments (TLR2 for up to 3 hours) and serum/albumin depletion controls.

Limitations

• The dataset is provided as a 1.3 MB PDF, requiring manual extraction of any underlying numerical or tabular data.
• Row and column counts are unknown, making suitability for computational analysis difficult to assess.
• The description lacks explicit column-level documentation for any underlying data tables.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from mass spectrometry and cell culture assays described in the associated research.

Freshness

Last updated 2026-06-01 04:18:56