Functional Cell Model for Omalizumab Response in Pediatric Asthma

A 1.3 MB PDF dataset from figshare, last updated March 2026, describes an in vitro functional cell model to study molecular mechanisms of response to omalizumab treatment. The research, authored by Boris Gole, uses basophil activation tests and RNA sequencing from asthmatic children and adolescents to identify biomarkers like RSAD2 expression. The dataset is shared under a CC-BY-4.0 license.

Use Cases

• Identify biomarkers for omalizumab response based on basophil-specific RNA sequencing data.
• Model differential patient responses to biological therapy using in vitro basophil activation and degradation test results.
• Validate gene expression signatures, such as low RSAD2 expression, associated with poor treatment response.

Strengths

• Dataset is shared under a permissive CC-BY-4.0 license.
• Research methodology is described in detail, including basophil activation tests and RNA sequencing.
• Findings were validated in an independent patient cohort.

Limitations

• Row count and column-level documentation are unknown.
• The primary data format is a 1.3 MB PDF, which may require extraction of underlying data.
• Data may reflect bias inherent to the specific pediatric asthma cohort studied.

Provenance

Source

figshare, author Boris Gole.

Collection Method

White blood cells were isolated from asthmatic children and adolescents, pre-treated with omalizumab, and analyzed via basophil activation tests and RNA sequencing.

Freshness

Last updated 2026-03-18 07:42:37.