Hedgehog Cathelicidin Peptide Antiviral Activity Against HSV-1

Enjie Deng's 2026 figshare publication details the antiviral activity of hedgehog cathelicidin-derived peptides against herpes simplex virus type 1. The study identifies CathEE-2a as a lead candidate, showing in vitro antiviral effects and reduced brain viral loads in a mouse model. The dataset is a 970.6 KB PDF containing the full research article.

Use Cases

• Analyze CathEE-2a's antiviral activity data from in vitro experiments and mouse infection models.
• Review histopathological analyses of HSV-1-induced brain damage attenuation by CathEE-2a.
• Study the mechanistic data on CathEE-2a upregulating type I interferons and downstream antiviral genes.
• Compare the designed antiviral peptides CathEE-1, CathEE-2, CathEE-3, CathEE-2a, and CathEE-2b.

Strengths

• Contains specific, peer-reviewed findings on a novel antiviral peptide candidate (CathEE-2a).
• Data is recent, with a last update in March 2026.
• Published under a permissive CC BY 4.0 license for reuse.

Limitations

• The dataset is a single 970.6 KB PDF, not a structured, machine-readable table for direct analysis.
• No raw experimental data (e.g., numerical results, sequences) is provided in a tabular format.
• Scope is limited to the specific study of hedgehog cathelicidin peptides against HSV-1.

Provenance

Source

Enjie Deng via figshare.

Collection Method

Experimental research involving European hedgehog skin extract, peptide design, in vitro assays, and a mouse infection model.

Time Range

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Freshness

Last updated 2026-03-23.

Geography

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