Meta-Analysis and Expression Profiling of DNA Repair Gene Polymorphisms in Leukemia

A meta-analysis of 54 studies from PubMed, Web of Science, Scopus, and Cochrane Library up to December 3, 2025, investigating associations between DNA repair gene polymorphisms and leukemia risk. Gene expression analyses were performed using Leukemia DB, GEPIA2, and BloodSpot datasets. The dataset, a 681.7 KB DOCX file, was authored by Honghui Ye and last updated on April 23, 2026.

Use Cases

• Identifying leukemia risk associations based on DNA repair gene polymorphisms like XPD Lys751Gln and XRCC1 Arg399Gln.
• Analyzing subtype-specific expression patterns of DNA repair genes mentioned in the results.
• Validating potential biomarkers for leukemia risk stratification based on the conclusions.
• Conducting secondary meta-analyses on the association between specific polymorphisms and disease risk.

Strengths

• Meta-analysis includes 54 studies, providing a systematic review of the literature.
• Gene expression validation was performed across three distinct datasets: Leukemia DB, GEPIA2, and BloodSpot.
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• The primary data file is a 681.7 KB DOCX document, which is a small-scale text summary rather than raw data.
• Column-level documentation and sample data are unavailable, requiring manual inspection after download.
• Row count is unknown, limiting suitability assessment for direct computational analysis.

Provenance

Source

figshare

Collection Method

Systematic literature search and meta-analysis, supplemented with gene expression analysis from public databases.

Time Range

Studies included up to December 3, 2025.

Freshness

Last updated 2026-04-23 04:21:47

Geography

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