eoPRED: Placental DNA Methylation Scores for Early-Onset Preeclampsia

A dataset of 493 placental samples with DNA methylation scores and histopathologic characterization. The eoPRED score is associated with early-onset preeclampsia and maternal vascular malperfusion pathology. The data was contributed by Hannah J. Illing and last updated on 2026-06-04.

Use Cases

• Validate the eoPRED DNA methylation score as a biomarker for early-onset preeclampsia based on the described case-control comparison.
• Investigate associations between placental DNA methylation and maternal vascular malperfusion pathology severity independent of preeclampsia diagnosis.
• Use the eoPRED score as a proxy for placental dysfunction in datasets lacking detailed pathology information, as suggested in the discussion.

Strengths

• Includes 493 placental samples with paired DNA methylation and histopathologic data.
• The eoPRED score showed a statistically significant correlation (R=0.34, p<0.01) with maternal vascular malperfusion grade.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 17.8 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Infinium EPICv1.0 DNA methylation data and histopathologic characterization by a placental pathologist.

Freshness

Last updated 2026-06-04 22:01:25; freshness should be verified.