SCRATCH-HTN Trial Protocol for Transcutaneous Vagus Nerve Stimulation in Hypertension

63 hypertensive patients were randomized 2:1 in the SCRATCH-HTN double-blind, sham-controlled trial evaluating transcutaneous autonomic neuromodulation. The study protocol, authored by Ajay Gupta and registered with ClinicalTrials.gov (NCT05179343), was last updated in April 2026. It details the methodology, endpoints, and exploratory outcomes for this phase 2a investigation.

Use Cases

• Analyze the relationship between daytime ambulatory systolic blood pressure change (primary endpoint) and treatment group assignment.
• Model associations between secondary endpoints like heart rate variability, sleep quality scores, and the administered therapy.
• Evaluate protocol-defined inclusion criteria, such as systolic BP between 135 and 170 mmHg, for patient cohort simulation.
• Study the correlation between exploratory outcomes, including 6-minute walk test results and cardiac structural changes, from the subgroup analysis.

Strengths

• Documented study design for a double-blind, randomized controlled trial with 63 participants.
• Protocol registered with two authoritative sources: ClinicalTrials.gov (NCT05179343) and ISRCTN (14509154).

Limitations

• Dataset is a 234.8 KB study protocol document (DOCX), not the underlying patient-level clinical trial data.
• The temporal coverage and specific results of the trial are not contained within this file.

Provenance

Source

figshare, authored by Ajay Gupta.

Collection Method

Published study protocol for a clinical trial.

Time Range

Covers the planned study period for the SCRATCH-HTN trial.

Freshness

Protocol document was last updated on 2026-04-08.

Geography

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