Standardized Rat Model of Maxillary Anterior Periodontal Soft Tissue Defect

A 7.5 MB PDF document authored by Ruoxuan Huang and last updated in April 2026. The paper describes the establishment of a standardized, minimally invasive rat model for evaluating soft tissue graft materials in dentistry. The model involves creating a 4 × 2 mm soft tissue defect in the maxillary anterior labial region and assessing healing through clinical observation and histological analyses.

Use Cases

• Benchmarking new soft tissue graft materials based on the described standardized defect model.
• Studying biological responses like angiogenesis and immune response during soft tissue regeneration as outlined in the methods.
• Comparing healing patterns of autografts versus xenografts using the clinical and histological evaluation framework.
• Screening graft material performance in early-stage research prior to large-animal studies as suggested by the discussion.

Strengths

• Provides a detailed methodological protocol for creating a standardized 4 × 2 mm defect.
• The model is described as having low complication rates and high reproducibility.
• Includes evaluation through multiple techniques: clinical observation, H&E staining, Masson’s trichrome staining, and immunohistochemistry.

Limitations

• The dataset is a single 7.5 MB PDF; the underlying raw experimental data (e.g., measurements, images) is not directly provided.
• Column-level documentation is absent; field semantics must be inferred from the paper's text.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

figshare

Collection Method

Research study involving anatomical assessment, surgical defect creation, and histological analysis in rats.

Time Range

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Freshness

Last updated 2026-04-20 05:23:12; freshness should be verified.

Geography

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