Wengxian Granules: Systems Pharmacology Study for Avian Salmonellosis

A 1.2 MB research document details a systems pharmacology study of Wengxian granules against avian salmonellosis. The study, authored by Siting Pu and last updated in March 2026, identifies 40 active compounds and 66 potential therapeutic targets. It describes experimental results on blood cell counts, immunoglobulin levels, and cecal mucosa integrity in an infection model.

Use Cases

• Validate network pharmacology predictions based on the 40 identified active compounds and 66 targets.
• Study the immunological mechanisms of herbal treatments based on described IgM, IgG, and sIgA level changes.
• Perform molecular docking simulations based on the core targets and active compounds like kaempferol and quercetin.
• Investigate the role of Toll-like and NOD-like receptor signaling pathways in avian disease treatment.

Strengths

• Identifies 40 active compounds and 66 potential therapeutic targets.
• Provides specific immunological and histological results from an in vivo model.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Data is presented in a 1.2 MB DOCX file; column-level data and row counts are unknown.
• Description metadata is limited; actual data quality requires manual inspection after download.
• The dataset's small size (1.2 MB) suggests it is a document, not a large-scale data repository.

Provenance

Source

Siting Pu via figshare

Collection Method

Experimental study combining in vivo assessment, network pharmacology analysis, and molecular docking.

Freshness

Last updated 2026-03-18 05:34:49; freshness should be verified.