TSCP: Traditional Sore-Throat Phytoextract Effects in a Mouse Model

A 505.1 KB research document by Xinyu Zhang, last updated in May 2026, details the effects of a traditional sore-throat composite phytoextract (TSCP) on acute pharyngitis in mice. The study provides specific Minimum Inhibitory Concentration (MIC) values for TSCP against S. aureus (32 μg/mL), MRSA (64 μg/mL), and E. coli (256 μg/mL). It combines network pharmacology analysis with in vitro antimicrobial assays and in vivo molecular validation of the PI3K/AKT/NF‑κB signaling pathway.

Use Cases

• Training models to predict bioactive components from herbal formulas based on network pharmacology results.
• Analyzing dose-response relationships for anti-inflammatory effects based on behavioral and histopathological outcomes in mice.
• Benchmarking in vitro antibacterial efficacy based on reported MIC and MBC values against drug-resistant strains.
• Studying pathway modulation in inflammatory diseases based on validated changes in PI3K/AKT/NF‑κB signaling and downstream mediators.

Strengths

• Provides specific quantitative results, including MIC values of 32, 64, and 256 μg/mL against three bacterial strains.
• Describes a dual-mechanism experimental approach combining in vivo mouse models, network pharmacology, and in vitro assays.
• Document is under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a 505.1 KB DOCX file, indicating a limited scope focused on a single study's results.
• Row count and column-level documentation are absent; data structure must be inferred from the textual description.
• The data is derived from a controlled mouse model, which may not directly translate to human clinical outcomes.

Provenance

Source

figshare, author Xinyu Zhang.

Collection Method

Experimental research employing an ammonia-induced acute pharyngitis murine model, network pharmacology, and in vitro assays.

Time Range

Study period not specified; document posted in 2026.

Freshness

Last updated 2026-05 22 05:58:10; freshness should be verified.

Geography

Geographic origin of the study or data is not specified.