Mouse Prenatal Stress Effects on Microbiome and Cytokine Expression

Audrey F. Duff published a dataset on figshare in 2026. It contains results from a mouse model of prenatal stress, assessing intestinal microbiome composition alongside intestinal and lung cytokine gene expression over the first five weeks of life. The findings link stress-mediated microbiome changes to respiratory and ileal immune development.

Use Cases

• Analyze correlations between microbiome diversity and cytokine gene expression based on the described microbial and cytokine assessments.
• Investigate MyD88 pathway-dependent immune responses based on the comparison with MyD88-deficient offspring.
• Model the relationship between prenatal stress and proinflammatory gene signatures based on the reported interferon and cytokine differences.
• Study longitudinal changes in microbial colonization and immune markers based on the five-week assessment period.

Strengths

• Data is derived from a controlled mouse model experiment, allowing for mechanistic investigation.
• Analysis includes both microbiome diversity and cytokine gene expression in two tissues (ileum and lung).
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 8.8 MB size suggests a relatively small dataset.

Provenance

Source

figshare

Collection Method

Experimental data from a mouse model of prenatal stress.

Time Range

Observations over the first five weeks of life.

Freshness

Last updated 2026-04-09 05:15:40; freshness should be verified.