Data Sheet 1: Coronary Artery Calcium and Polygenic Risk Score for MACE Prediction

A retrospective cohort of 1,380 predominantly Caucasian participants from the Sanford Health System was analyzed to compare the predictive utility of coronary artery calcium score (CACS) and coronary artery disease polygenic risk score (PRS) for major adverse cardiovascular events (MACE). The dataset, authored by Andrii Maryniak and last updated in June 2026, contains results showing the combination of CACS and PRS significantly enhanced predictive accuracy over either modality alone.

Use Cases

• Compare the predictive performance of CACS and CAD PRS for MACE based on the study's statistical analysis.
• Validate a combined risk model integrating genetic and imaging biomarkers based on the described synergistic effect.
• Assess the clinical utility of novel risk markers for primary prevention strategies based on the study's objectives.

Strengths

• Dataset is based on a cohort of 1,380 participants.
• Results include statistical metrics like area under the curve (AUC) for model comparison.
• License is CC-BY-4.0, allowing for broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The cohort is described as predominantly Caucasian, which may limit generalizability to other populations.

Provenance

Source

figshare

Collection Method

Retrospective analysis of a cohort from the Sanford Health System.

Freshness

Last updated 2026-06-04 11:37:02; freshness should be verified.

Geography

United States (Sanford Health System)