Canine Oral Melanoma Cell Lines for Adenovirus-Mediated Gene Therapy

Otavio Augusto Rodrigues published a research dataset on 2026-05-28. The data likely contains results from characterizing two newly established canine oral melanoma cell lines, BAN and TIG. It includes findings on their oncogenic properties, p53 status, and responses to adenovirus-mediated delivery of p14ARF and interferon-β gene therapy.

Use Cases

• Modeling spontaneous canine cancer biology based on the described cell line heterogeneity and similarity to human cancers.
• Evaluating adenovirus vector transduction efficiency using the described RGD-modified non-replicating adenoviral vectors.
• Assessing p53 pathway activity in response to treatment based on the described expression of target genes CDKN1A and MDM2.
• Testing immunogenic cell death markers in vitro following gene therapy with p14ARF and IFNβ.
• Studying in vivo tumor progression reduction in nude mice models treated with in situ gene therapy.

Strengths

• Includes data from two distinct, newly established cell lines (BAN and TIG) providing comparative insights.
• Contains in vitro and in vivo experimental results, including tumorigenicity tests in nude mice.
• Results are linked to specific molecular pathways (p53, p14ARF, IFNβ) and therapeutic vectors.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data is contained within a 1.4 MB PDF, which may require extraction and structuring for analysis.

Provenance

Source

figshare

Collection Method

Data was generated from laboratory experiments isolating and characterizing cell lines, followed by in vitro and in vivo gene therapy studies.

Freshness

Last updated 2026-05-28 06:17:14; freshness should be verified.