B-Cell Profiles in Older Adults with Immune Thrombocytopenia

A research article analyzing B-cell profiles in patients with immune thrombocytopenia (ITP). The study compares patients over 65 and under 65 with age-matched healthy controls to distinguish disease-specific from age-related changes. The document was authored by E. Monzón Manzano and last updated on May 12, 2026.

Use Cases

• Comparing B-cell subset distributions between older and younger ITP patients based on the described patient groups
• Investigating the relationship between plasma B-cell activating factor levels and disease state as mentioned in the results
• Analyzing the expansion of CD21-CD24- naïve B-cell subsets as a potential ITP biomarker described in the conclusion

Strengths

• The study design includes age-matched healthy control groups for comparison, as described in the introduction.
• Specific B-cell subsets and markers are identified, such as CD21-CD24- naïve B cells and immature/transitional subsets.
• The document is licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• The dataset is a 418.1 KB PDF document, which is a small-scale, single-file publication rather than a structured data table.
• Column-level documentation and sample data are unavailable, requiring manual extraction of any quantitative data.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

figshare

Collection Method

Blood samples were processed and stained using EuroFlow protocols, as described in the methods.

Freshness

Last updated 2026-05-12 05:42:56; freshness should be verified.