Data Sheet 1_Altered early-life gut microbiota in offspring of pregnancies complicated by

A 2026 study by Yiyang Han compared the initial gut microbiota of 40 neonates. It includes 16S rRNA sequencing data from meconium samples of 23 neonates born to mothers with congenital heart disease-associated pulmonary arterial hypertension (PH group) and 17 neonates from a control group (NC group). The dataset contains microbial diversity indices and relative abundance data at phylum and genus levels.

Use Cases

• Compare alpha diversity metrics (Shannon, observed features) between neonatal groups based on maternal health status.
• Analyze differences in genus-level microbial composition, such as the relative abundance of Streptococcus.
• Investigate predicted functional metabolic pathways, like ubiquinone biosynthesis, that may differ between groups.
• Study the association between maternal pulmonary hypertension and the establishment of the early-life gut microbiome.

Strengths

• Includes data from 40 distinct meconium samples (23 PH, 17 NC), providing a basis for group comparison.
• Contains specific, statistically significant findings, such as a lower mean relative abundance of Streptococcus in the PH group (0.20% vs. 2.09%).
• Uses 16S rRNA sequencing, a standard method for microbial community profiling.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is very small at 12.7 KB, indicating limited scope and likely summary-level data rather than raw sequences.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

Yiyang Han via figshare

Collection Method

First-pass meconium samples were collected from neonates and characterized using 16S rRNA sequencing.

Freshness

Last updated 2026-05-29 06:11:29; freshness should be verified.