Data Sheet 1: Transcriptomic and Histological Data from a Rat Model of CKD Cardiomyopathy

A 323.4 KB document under CC-BY-4.0 license details experimental data from a study on pegmolesatide's effects on cardiomyopathy in a chronic kidney disease rat model. The study, authored by Xinyu Zhang and last updated May 13, 2026, involved four rat groups, echocardiography, histopathology, serum assays, Western blot, qPCR, and transcriptomic sequencing. Results indicate cardioprotective effects mediated via JAK2/STAT3 inhibition and mitochondrial function improvement.

Use Cases

• Analyze transcriptomic sequencing results related to mitochondrial function and STAT3 signaling pathways.
• Compare cardiac functional parameters from echocardiography across sham and CKD model groups.
• Investigate correlations between serum renal function parameters and myocardial fibrosis/hypertrophy markers.
• Validate in vitro findings from AC16 human cardiomyocyte experiments using serum from CKD patients.

Strengths

• The dataset is associated with a detailed experimental design involving four distinct rat groups and multiple analysis methods.
• It includes results from transcriptomic sequencing, which likely provides a broad molecular profile.

Limitations

• The dataset is a single 323.4 KB DOCX file, suggesting limited raw data scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Data generated from a 5/6 nephrectomy rat model of CKD, with subsequent biochemical, histological, and molecular analyses.

Freshness

Last updated 2026-05-13 05:35:31; freshness should be verified.