Axolotl Immunoglobulin Loci Characterization Based on Improved Genome Assembly

A research paper presents an updated genomic characterization of immunoglobulin loci in the Ambystoma mexicanum (axolotl) species. The analysis is based on a novel 29.1 Gbp genome assembly (UKY_AmexF1_1) and includes manual curation and refinement using RNA-Seq data from multiple tissues. The work was authored by Stephanie Saint Remy-Hernández and last updated on March 17, 2026.

Use Cases

• Comparative analysis of immunoglobulin gene loci based on the description of synteny and orientation differences between genome assemblies.
• Investigating intraspecies structural variation based on the reported differences in lambda locus cluster counts.
• Studying immune gene evolution in amphibians based on the characterization of IGH and IGL loci in the axolotl reference genome.

Strengths

• Analysis is based on an improved genome assembly containing only 220 unmapped scaffolds.
• Gene models were refined using RNA-Seq datasets from five axolotl tissues (spleen, liver, lung, heart, gill).
• The IGH locus was precisely mapped to a 14 Mbp region (350–364 Mbp) on chromosome 13q.

Limitations

• The dataset is a 770.6 KB PDF document, which is a small-scale research summary rather than raw genomic data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare

Collection Method

Alignment-based annotation and manual curation performed on the UKY_AmexF1_1 genome assembly.

Time Range

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Freshness

Last updated 2026-03-17 13:06:58; freshness should be verified.

Geography

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