GWAS of BMI in an Admixed Brazilian Population with Functional Validation

Samantha Kuwada Teixeira's research data sheet describes a genome-wide association study of body mass index in 1,079 admixed Brazilian individuals. The study identified three genome-wide significant loci and functionally characterized a regulatory variant at the KCNB1 gene influencing adipogenesis. The dataset was last updated on 2026-05-07.

Use Cases

• Prioritizing candidate genes for obesity based on GWAS results and epigenomic annotation described in the study.
• Studying ancestry-specific genetic mechanisms based on the enrichment of the rs149309426 risk allele in individuals with African ancestry.
• Investigating the role of KCNB1 in adipocyte differentiation using findings from pharmacological inhibition and mouse knockout models.
• Replicating integrative analysis of BMI-associated loci using chromatin conformation and allele-specific regulatory activity data.

Strengths

• Study includes functional validation through luciferase assays, electrophoretic mobility shift assays, and in vitro/in vivo models.
• GWAS was conducted on a cohort of 1,079 individuals, identifying three loci at genome-wide significance (p ≤ 5 × 10⁻⁸).
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• The primary data file is a 2.0 MB DOCX document; underlying raw or processed genomic data is not directly available in this record.
• Row count and column-level documentation for any potential supplementary data are unknown.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Samantha Kuwada Teixeira via figshare

Collection Method

Genome-wide association study (GWAS) and functional genomic assays.

Freshness

Last updated 2026-05-07 04:45:05; freshness should be verified.

Geography

Admixed Brazilian population