Bat Immunoglobulin Loci Annotations and BCR-CDR3 Repertoire Characteristics

Rhinolophus ferrumequinum and Antrozous pallidus bats provide chromosome-level annotations of immunoglobulin heavy (IGH) and light (IGK/IGL) loci. The dataset, created by QinLu Liu and last updated in May 2026, includes BCR CDR3 repertoire data from spleen and intestinal tissues of Hipposideros armiger and Rhinolophus pearsonii/pusillus, generated via 5'RACE and high-throughput sequencing.

Use Cases

• Comparative evolutionary analysis of immunoglobulin loci based on annotated V, D, J, and constant region genes.
• Analysis of BCR CDR3 repertoire diversity and V/J gene usage patterns based on high-throughput sequencing data from bat tissues.
• Identification of conserved and distinct CDR3 motifs and amino acid distributions based on comparisons with human and mouse repertoires.

Strengths

• Provides first chromosome-level annotations for IGK and IGL loci in Rhinolophus ferrumequinum and IGH/IGL loci in Antrozous pallidus.
• Includes comparative analysis of BCR CDR3 repertoires against human and mouse, highlighting specific differences like N/P nucleotide patterns.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Dataset is a 52.0 KB DOCX file, suggesting limited raw data; primary annotations and analysis are likely in textual format.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The specific data files and their formats beyond the summary document are not described.

Provenance

Source

figshare

Collection Method

Chromosome-level annotation and 5' Rapid Amplification of cDNA Ends (5'RACE) with high-throughput sequencing.

Time Range

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Freshness

Last updated 2026-05-20 04:34:13

Geography

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