LSEC Immune Tolerance Study Data from Mouse and Human Liver Fibrosis Models

Cornelia Gottwick's research paper investigates liver sinusoidal endothelial cell (LSEC) functions in fibrotic conditions. The 4.4 MB PDF document presents results from two mouse models of liver fibrosis and analysis of datasets from human subjects. Findings confirm LSECs maintain scavenger activity and antigen-specific tolerance induction despite fibrosis.

Use Cases

• Validate LSEC tolerance mechanisms based on mouse model experiments described in the paper
• Assess nanoparticle uptake efficiency in fibrotic liver environments based on the described in vivo studies
• Compare immune pathway preservation between mouse models and human cirrhosis datasets referenced in the results

Strengths

• Data includes results from two distinct mouse models of liver fibrosis.
• Analysis incorporates confirmation from datasets of human subjects with or without liver cirrhosis.
• The document is licensed under CC-BY-4.0 for open sharing.

Limitations

• The primary data format is a PDF, which may require extraction for computational analysis.
• Row count and column-level documentation are unknown.
• The dataset's scale is limited to 4.4 MB.

Provenance

Source

figshare

Collection Method

Research experiments utilizing mouse models and analysis of existing human datasets.

Freshness

Last updated 2026-05-05 04:13:32