APOE ε4 and Hippocampal Volume Interaction in Alzheimer's Cognitive Decline

2,417 Alzheimer’s Disease Neuroimaging Initiative participants with longitudinal cognitive assessments over a mean follow-up of 4.2 years. The dataset, authored by Faizaan Fazal Khan and last updated in April 2026, likely contains clinical and neuroimaging data used to analyze the interaction between APOE ε4 genotype and hippocampal volume on cognitive trajectories.

Use Cases

• Modeling longitudinal cognitive decline based on APOE ε4 dose and hippocampal volume mentioned in the description
• Assessing conversion risk to Alzheimer's disease using Cox proportional hazards models described in the methods
• Training models to predict cognitive scores (MMSE, CDR-SB, ADAS-Cog13) from genetic and structural brain data
• Investigating statistical interactions between genetic risk factors and brain atrophy for biomarker discovery

Strengths

• Data from 2,417 participants provides a substantial sample size for analysis
• Longitudinal design with a mean follow-up of 4.2 years and up to 19.3 years of observation
• Includes multiple standardized cognitive assessments (MMSE, CDR-SB, ADAS-Cog13)
• Analysis methods, including linear mixed-effects models, are described in detail

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The primary file format is DOCX, which may require conversion for typical data science workflows

Provenance

Source

Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Collection Method

Clinical and neuroimaging data collection from a longitudinal observational study

Time Range

Longitudinal assessments spanning up to 19.3 years

Freshness

Last updated 2026-04-22 05:46:22; freshness should be verified

Geography

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