Spinal Sympathetic Neuron Calcium Activity During Locomotor Activity

Calcium fluorescence recordings from thoracic sympathetic preganglionic neurons (SPNs) during pharmacologically evoked locomotor activity in an in vitro spinal cord preparation. The data compares SPN responses across thoracic segments (T4-T11) under tonic and rhythmic conditions.

Use Cases

• Analyze normalized calcium fluorescence (Ca-RI) changes in SPNs across thoracic segments (T4-T11) to map segmental activation patterns.
• Compare SPN Ca-RI responses between rostral (T4-T7) and caudal (T8-T11) segments during tonic locomotor activity.
• Investigate the trimodal distribution of SPN Ca-RI, with peaks at mid-thoracic segments (T6-7), during rhythmic locomotor activity.
• Correlate lumbar ventral root (VR) activity recordings with thoracic SPN Ca-RI to study ascending propriospinal modulation.

Strengths

• Data is derived from a controlled in vitro spinal cord preparation, allowing for isolated study of neural circuits.
• Examines SPN activity across multiple thoracic segments (T4 through T11), providing spatial resolution.
• Includes comparisons under two distinct experimental conditions: tonic and rhythmic locomotor activity.

Limitations

• The dataset is very small (54.6 KB), indicating limited scope and likely a small sample size of experimental recordings.
• Data is presented in a PDF format, which is not machine-readable or readily analyzable without manual extraction.
• Findings are specific to an in vitro animal model, which may not fully translate to in vivo human physiology.

Provenance

Source

figshare, authored by Lucia E. Dominguez-Rodriguez.

Collection Method

Data collected from in vitro spinal cord preparations using calcium imaging of pre-labelled SPNs and lumbar ventral root recordings during pharmacologically evoked locomotor activity.

Freshness

Last updated on 2026-03-20.