Data Sheet 1: Molecular Pathways in Spontaneous Lupus Mouse Models

A study by María Rivas-Torrubia integrates longitudinal molecular data from four spontaneous systemic lupus erythematosus (SLE) mouse models—MRLlpr/lpr, NZB/W, BXSB.Yaa, and Tlr7.Tg6—with human data from the PRECISESADS cohort. The dataset includes transcriptome sequencing from blood, spleen, and kidney, flow cytometry, and plasma cytokine and autoantibody measurements across four time points. It was last updated on May 13, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Identify translational disease-relevant pathways based on comparative analysis of mouse and human molecular signatures.
• Select optimal experimental time points for mouse studies based on the described dynamics of phenotype-associated molecular signatures.
• Investigate disease severity correlates based on the extent and timing of molecular dysregulations across models.
• Study model-specific immune features such as age-associated B cells and double-negative memory T cells in relation to early disease processes.

Strengths

• Longitudinal design with data collected at four distinct time points per model.
• Multimodal data integration includes transcriptomics, flow cytometry, and plasma measurements.
• Direct comparison framework established with human SLE data from the PRECISESADS cohort.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 7.1 MB file size suggests a small dataset, potentially limiting the scope of analysis.

Provenance

Source

figshare

Collection Method

Experimental data from four spontaneous SLE mouse models integrated with human cohort data.

Freshness

Last updated 2026-05-13 05:58:09; freshness should be verified.