Meta-Analysis of Vancomycin-Piperacillin/Tazobactam and Acute Kidney Injury Risk

A meta-analysis of 35 studies with 39,554 patients compares acute kidney injury incidence across vancomycin-based antibiotic regimens. The study, authored by Chao-Hai Wang and last updated in May 2026, pools data from PubMed, Embase, and Cochrane up to November 2025. It reports the highest pooled AKI incidence for vancomycin-piperacillin/tazobactam combination therapy, with subgroup analyses by geographic region and clinical setting.

Use Cases

• Assessing comparative nephrotoxicity risk of vancomycin combination therapies based on reported pooled incidence rates.
• Investigating geographic variation in drug safety outcomes based on subgroup analyses for Europe, North America, and Asia.
• Analyzing differential risk in intensive care unit (ICU) versus non-ICU patient populations based on the described clinical setting subgroups.
• Supporting antibiotic selection decisions by modeling the risk of acute kidney injury associated with specific regimens.

Strengths

• Includes data from 35 studies encompassing 39,554 patients, providing a substantial evidence base.
• Reports specific pooled incidence rates with 95% confidence intervals for multiple antibiotic regimens, such as 25.50% for VPT.
• Conducts subgroup analyses by geographic region (e.g., Europe 41.30%) and clinical setting (e.g., ICU 33.80%), adding analytical depth.

Limitations

• The primary data file is a 1.6 MB DOCX document; the underlying structured dataset (e.g., patient-level or study-level data) is not directly available.
• Column-level documentation is absent; field semantics must be inferred after download from the manuscript text.
• Row count for any underlying data is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

figshare, authored by Chao-Hai Wang.

Collection Method

A comprehensive literature search and meta-analysis of studies from PubMed, Embase, and Cochrane.

Time Range

Literature search from database inception up to November 30, 2025.

Freshness

Last updated 2026-05-21 04:37:09; freshness should be verified.

Geography

Global, with subgroup analyses for Europe, North America, and Asia.