Gut Microbiota and Imaging Biomarkers in Cerebral Small Vessel Disease with Hydrocephalus

95 subjects' gut microbiota profiles and cerebral imaging markers for arteriosclerotic cerebral small vessel disease (aCSVD) and idiopathic normal pressure hydrocephalus (iNPH). Jiaxin Cai published this research data on figshare in May 2026. The study identifies differential microbial abundances and their correlations with imaging indicators like cerebral microbleeds and deep medullary vein scores.

Use Cases

• Training diagnostic models to distinguish aCSVD-iNPH from aCSVD based on differential microbial taxa like Thermus and Saccharomyces.
• Analyzing Spearman correlations between specific gut bacteria (e.g., Solobacterium) and neuroimaging markers (e.g., cerebral microbleeds).
• Investigating beta-diversity differences in gut microbiota between patient groups as described in the results.
• Validating preliminary findings on microbial biomarkers for cerebral small vessel disease in independent cohorts.

Strengths

• Includes data from 95 enrolled subjects, providing a basis for statistical analysis.
• Reports specific correlation results, such as the negative correlation between Solobacterium abundance and cerebral microbleeds (r = -0.292).
• Contains results from ROC analysis with AUC values (e.g., 0.716 for Thermus) for diagnostic model assessment.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (11.6 KB), indicating limited raw data or a summary document.

Provenance

Source

figshare, author Jiaxin Cai.

Collection Method

Fresh fecal samples collected for microbial DNA extraction and 16S rDNA sequencing; imaging biomarkers assessed.

Time Range

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Freshness

Last updated 2026-05-08 05:52:08; freshness should be verified.

Geography

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