TyG Index Association with Diabetic Foot Ulcers in Hospitalized T2D Patients

497 adult inpatients with type 2 diabetes were studied in a dual-center, retrospective case-control analysis. The dataset examines the relationship between the triglyceride-glucose (TyG) index and the presence of diabetic foot ulcers (DFU). It includes 106 cases with DFU and 391 controls without, with data collected between 2014 and 2023.

Use Cases

• Assess the TyG index's discriminative ability for predicting DFU using the provided AUC, sensitivity, and specificity metrics.
• Build a logistic regression model to predict DFU status using the TyG index and TyG-BMI index as independent variables.
• Analyze the association between DFU presence and clinical markers like TyG index, comparing mean values between the DFU and non-DFU groups.
• Investigate the odds ratio for DFU presence associated with the TyG index as derived from multivariate logistic regression models.

Strengths

• Contains data from 497 adult inpatients, providing a substantial clinical cohort for analysis.
• Includes clearly defined case (n=106) and control (n=391) groups for comparative study.
• Reports specific statistical results, including mean TyG index values, p-values, AUC (0.61), and odds ratios (e.g., OR=2.18).
• Covers a multi-year time range from 2014 to 2023 across two hospital centers.

Limitations

• The dataset is static and derived from a retrospective study, limiting causal inference.
• Sample size for the DFU case group (n=106) is relatively small compared to the control group, which may affect the power of some subgroup analyses.
• Geographic scope is limited to patients from two hospitals, which may not be generalizable to other populations.

Provenance

Source

Retrospective case-control study by Alessandro De Stefano, shared via figshare.

Collection Method

Dual-center, retrospective analysis of consecutively admitted adult inpatients with type 2 diabetes.

Time Range

Data collected during different periods between 2014 and 2023.

Freshness

Data last updated in the source system on 2026-03-23, though the study period ended in 2023.

Geography

Patients admitted to two hospitals; specific location not stated but implied to be Albanian based on prior research context.